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Discovery to Mass Production: A Perspective on Bio-Manufacturing Exemplified by the Development of Statins Review

Xiaoling Tang, Jiawei Yu, Yuheng Geng, Jiarui Wang, Renchao Zheng, Yuguo Zheng

Engineering 2023, Volume 24, Issue 5,   Pages 138-150 doi: 10.1016/j.eng.2022.04.030

Abstract: The development of statins—important drugs for hypercholesterolemia treatment—is a good exampleThe production of the first-generation statins from microorganisms, the second-generation statins usingbioconversion, and the third-generation statins through an evolution from total chemical synthesis to

Keywords： Bio-manufacturing     Statins     Microorganisms     Bioconversion     Chemoenzymatic synthesis    

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Discovery to Mass Production: A Perspective on Bio-Manufacturing Exemplified by the Development of Statins

Xiaoling Tang, Jiawei Yu, Yuheng Geng, Jiarui Wang, Renchao Zheng, Yuguo Zheng

Journal Article